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Functioning as a potent exercise mimetic, this small-molecule compound enhances mitochondrial function, fatty acid oxidation, and oxidative muscle fiber composition, thereby improving exercise endurance, cardiac metabolic efficiency, and systemic energy expenditure without increasing food intake 1-4

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High dose oral cobalamin may be a suitable alternative in selective cases, where intramuscular injections are not tolerated and compliance is not a problem

The Mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance